Article
Evidence for a major gene for bone mineral density/content in human pedigrees identified via probands with extreme bone mineral density.
Annals of human genetics - 1 Jan 2002
Deng H W, Livshits G, Yakovenko K, Xu F H, Conway T, Davies K M, Deng H, Recker R R
Abstract excerpt
Bone mineral content (BMC) and/or bone mineral density (BMD, i.e. BMC scaled by bone size) are major determinants for osteoporosis, which is a serious health problem. The major determinant of variation in BMD/BMC is genetic. The few studies now available are inconsistent in the identification and/or even in the existence of major gene(s) for BMD/BMC. In 51 human pedigrees with 941 individuals (526 measured for...
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