Article
Genetic determination of bone mineral density: evidence for a major gene.
The Journal of clinical endocrinology and metabolism - 1 Aug 2003
Nguyen Tuan V, Livshits Gregory, Center Jacqueline R, Yakovenko Konstantin, Eisman John A
Abstract excerpt
This study was designed to test the hypothesis of a major gene influence on the variation in bone mineral density (BMD). BMD and bone mineral content at the lumbar spine and femoral neck were measured in 330 men and 413 women, aged 18-90 yr, from 107 nuclear and complex families (including 5 large pedigrees with 194 individuals who were identified through an index case with moderately high BMD at the femoral neck...
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