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Article

Bivariate genome-wide linkage analysis of femoral bone traits and leg lean mass: Framingham study.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2009

Karasik David, Zhou Yanhua, Cupples L Adrienne, Hannan Marian T, Kiel Douglas P, Demissie Serkalem

Abstract excerpt

The risk of osteoporotic fracture is a function of both applied muscle mass and bone tissue distribution. Leg lean mass (LLM) and femoral bone geometry are both known to have substantial genetic components. Therefore, we estimated shared heritability (h(2)) and performed linkage analysis to identify chromosomal regions governing both LLM and bone geometry. A genome-wide scan (using 636 microsatellite markers) for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Inheritance Patterns

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Share to Quantitative Trait, Heritable

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Source

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Identifiers

PMID: 19063671
DOI: 10.1359/jbmr.081222
PMCID: PMC2659513

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