Article
Heritability of bone mineral density in a multivariate family-based study.
Calcified tissue international - 1 Jun 2014
Hernandez-de Sosa Nerea, Athanasiadis Georgios, Malouf Jorge, Laiz Ana, Marin Ana, Herrera Silvia, Farrerons Jordi, Soria Jose Manuel, Casademont Jordi
Abstract excerpt
There is evidence for a genetic contribution to bone mineral density (BMD×). Different loci affecting BMD have been identified by diverse linkage and genome-wide association studies. We studied the heritability of and the correlations among six densitometric phenotypes and four bone mass/fracture phenotypes. For this purpose, we used a family-based study of the genetics of osteoporosis, the Genetic Analysis of...
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