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Article

TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent.

Traffic (Copenhagen, Denmark) - 1 Jul 2008

Geetha Thangiah, Wooten Marie W

Abstract excerpt

Gaps in our knowledge exist regarding the degradation of the tropomyosin-regulated kinase A (TrkA) receptor after addition of neurotrophin, nerve growth factor (NGF). TrkA is rapidly and transiently ubiquitinated upon addition of NGF. Here, we demonstrate that the polyubiquitin tag plays a definitive role in receptor sorting. Treatment of PC12 cells with lactacystin prevented NGF-dependent deubiquitination and...

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Source

Identifiers

PMID: 18419753
DOI: 10.1111/j.1600-0854.2008.00751.x

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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