Article
Rab4 regulates formation of synaptic-like microvesicles from early endosomes in PC12 cells.
Molecular biology of the cell - 1 Nov 2001
de Wit H, Lichtenstein Y, Kelly R B, Geuze H J, Klumperman J, van der Sluijs P
Abstract excerpt
Early endosomes in PC12 cells are an important site for the formation of synaptic-like microvesicles and constitutive recycling vesicles. By immunogold electron microscopy, the small GTPase rab4 was localized to early endosomes and numerous small vesicles in the cell periphery and Golgi area of PC12 cells. Overexpression of GTPase-deficient Q67Lrab4 increased the number of early endosome-associated and...
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