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Article

Cholesterol and APOE genotype interact to influence Alzheimer disease progression.

Neurology - 25 May 2004

Evans R M, Hui S, Perkins A, Lahiri D K, Poirier J, Farlow M R

Abstract excerpt

In this retrospective analysis of 443 Alzheimer disease (AD) patients from a 30-week tacrine trial, change in Alzheimer's Disease Assessment Scale score from baseline to final value was significantly associated with a total serum cholesterol/APOE genotype interaction. Disease progression in the no-APOE epsilon4 allele/high-cholesterol subgroup was greater than in the normal-cholesterol subgroups with or without...

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Source

Identifiers

PMID: 15159498
DOI: 10.1212/01.wnl.0000125323.15458.3f

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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