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The role of DNA polymerase I in tolerating single-strand breaks generated at clustered DNA damage in Escherichia coli.

Scientific reports - 18 Aug 2024

Shikazono Naoya, Akamatsu Ken

Abstract excerpt

Clustered DNA damage, when multiple lesions are generated in close proximity, has various biological consequences, including cell death, chromosome aberrations, and mutations. It is generally perceived as a hallmark of ionizing radiation. The enhanced mutagenic potential of lesions within a cluster has been suggested to result, at least in part, from the selection of the strand with the mutagenic lesion as the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39155334
DOI: 10.1038/s41598-024-69823-4
PMCID: PMC11330960

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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