Evolution of human immunodeficiency virus type 1 populations after resumption of therapy following treatment interruption and shift in resistance genotype.

doi:10.1086/340215

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Article

Evolution of human immunodeficiency virus type 1 populations after resumption of therapy following treatment interruption and shift in resistance genotype.

The Journal of infectious diseases - 15 May 2002

Izopet Jacques, Souyris Corinne, Hance Allan, Sandres-Sauné Karine, Alvarez Muriel, Pasquier Christophe, Clavel François, Puel Jacqueline, Massip Patrice

Abstract excerpt

Conventional genotyping of human immunodeficiency virus type 1 often reveals a shift from a drug-resistant genotype to a wild-type genotype after treatment interruption. A real-time polymerase chain reaction-based technique was used to detect minority resistant populations in 13 patients who showed genotype reversion after interruption of treatment for 3 months. Sixty-two percent of patients in whom the V82A and...

Topics

Amino Acid Sequence
Anti-HIV Agents
Drug Resistance, Viral
Genome, Viral
Genotype
HIV Infections
HIV Protease
HIV-1
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymerase Chain Reaction

RNA-Directed DNA Polymerase

Refusal to Treat

Sequence Alignment

Sequence Homology, Amino Acid

Source

Open in PubMed

Identifiers

PMID: 11992288
DOI: 10.1086/340215

Provenance

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