Article
Evolution of human immunodeficiency virus type 1 populations after resumption of therapy following treatment interruption and shift in resistance genotype.
The Journal of infectious diseases - 15 May 2002
Izopet Jacques, Souyris Corinne, Hance Allan, Sandres-Sauné Karine, Alvarez Muriel, Pasquier Christophe, Clavel François, Puel Jacqueline, Massip Patrice
Abstract excerpt
Conventional genotyping of human immunodeficiency virus type 1 often reveals a shift from a drug-resistant genotype to a wild-type genotype after treatment interruption. A real-time polymerase chain reaction-based technique was used to detect minority resistant populations in 13 patients who showed genotype reversion after interruption of treatment for 3 months. Sixty-two percent of patients in whom the V82A and...
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