Article
Lack of persistent drug-resistant mutations evaluated within and between treatment interruptions in chronically HIV-1-infected patients.
AIDS (London, England) - 7 Nov 2003
Papasavvas Emmanouil, Grant Robert M, Sun Junwei, Mackiewicz Agnieska, Pistilli Maxwell, Gallo Cecile, Kostman Jay R, Mounzer Karam, Shull Jane, Montaner Luis J
Abstract excerpt
OBJECTIVE: To determine the effect of treatment interruptions (TI) on the evolution and persistence of drug-resistant viruses in chronically HIV-1-infected suppressed patients. METHODS: The emergence of viral resistance to combination antiretroviral therapy was monitored in 11 suppressed chronically HIV-1-infected patients undergoing from one up to four sequential TI (a total of 25 TI), by genotyping of the virus...
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