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Article

HIV-1 re-suppression on a first-line regimen despite the presence of phenotypic drug resistance.

PloS one - 1 Jan 2020

Basson Adriaan E, Charalambous Salome, Hoffmann Christopher J, Morris Lynn

Abstract excerpt

We have previously reported on HIV-1 infected patients who fail anti-retroviral therapy but manage to re-suppress without a regimen change despite harbouring major drug resistance mutations. Here we explore phenotypic drug resistance in such patients in order to better understand this phenomenon. Patients (n = 71) failing a non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimen, but who subsequently...

Topics

Adult
Anti-HIV Agents
Cohort Studies
Drug Resistance, Viral
Genotype
HIV Infections
HIV-1
Humans
Male
Phenotype
Reverse Transcriptase Inhibitors
Viral Load

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Identifiers

PMID: 32555643
DOI: 10.1371/journal.pone.0234937
PMCID: PMC7302689

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