Article
Biological role of phosphatase PTEN in cancer and tissue injury healing.
Frontiers in bioscience : a journal and virtual library - 1 May 2002
Tsugawa Kouji, Jones Michael K, Sugimachi Keizo, Sarfeh I James, Tarnawski Andrzej S
Abstract excerpt
PTEN (phosphatase and tensin homolog deleted on chromosome ten) also referred to as MMAC (mutated in multiple advanced cancers) was discovered as a tumor suppressor gene and later found to be a phospholipid phosphatase. PTEN negatively regulates Akt activation by preventing its phosphorylation. PTEN therefore inhibits the PI 3-kinase/Akt signaling pathway which is important for cell growth and survival....
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