Article
PTEN signaling pathways in melanoma.
Oncogene - 19 May 2003
Wu Heng, Goel Vikas, Haluska Frank G
Abstract excerpt
Phosphatase and tensin homolog deleted in from chromosome ten (PTEN), initially also known as mutated in multiple advanced cancers or TGF-beta-regulated and epithelia cell-enriched phosphatase, is a tumor suppressor gene that is mutated in a large fraction of human melanomas. A broad variety of human cancers carry PTEN alterations, including glioblastomas, endometrial, breast, thyroid and prostate cancers. The...
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