E1B-55K-deleted adenovirus expressing E1A-13S by AFP-enhancer/promoter is capable of highly specific replication in AFP-producing hepatocellular carcinoma and eradication of established tumor.

doi:10.1006/mthe.2002.0589

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Article

E1B-55K-deleted adenovirus expressing E1A-13S by AFP-enhancer/promoter is capable of highly specific replication in AFP-producing hepatocellular carcinoma and eradication of established tumor.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 May 2002

Takahashi Minoru, Sato Tsutomu, Sagawa Tamotsu, Lu Yue, Sato Yasushi, Iyama Satoshi, Yamada Yasuyuki, Fukaura Junki, Takahashi Sho, Miyanishi Koji, Yamashita Toshiharu, Sasaki Katsunori, Kogawa Katsuhisa, Hamada Hirofumi, Kato Junji, Niitsu Yoshiro

Abstract excerpt

Here, we constructed a recombinant replication-competent adenovirus (rRCAd; AdAFPep/Rep) that expresses both E1A-13S driven by the alpha-fetoprotein (AFP) enhancer/promoter (AFPep) lacking any silencers in the 5'-flanking region of the AFP gene, and 55K-deleted E1B driven by the cytomegalovirus (CMV) promoter. We then examined the feasibility of gene therapy utilizing this virus for AFP-producing hepatocellular...

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PMID: 11991754
DOI: 10.1006/mthe.2002.0589

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