Article
Target gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by E1B55k-attenuated adenovirus.
Biochemical and biophysical research communications - 30 Mar 2001
Ohashi M, Kanai F, Tateishi K, Taniguchi H, Marignani P A, Yoshida Y, Shiratori Y, Hamada H, Omata M
Abstract excerpt
Gene therapy using replication-competent adenovirus that selectively propagates in tumor cells may be an effective treatment for cancer. We developed an adenovirus that would be replication specific for hepatocellular carcinoma (HCC). Based on our finding that the E1B55k-deficient adenovirus was able to replicate in human primary hepatocytes, we therefore designed an adenovirus carrying E1A and attenuated E1B...
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