Article
High-level expression by tissue/cancer-specific promoter with strict specificity using a single-adenoviral vector.
Nucleic acids research - 1 Jan 2011
Kanegae Yumi, Terashima Miho, Kondo Saki, Fukuda Hiromitsu, Maekawa Aya, Pei Zheng, Saito Izumu
Abstract excerpt
Tissue-/cancer-specific promoters for use in adenovirus vectors (AdVs) are valuable for elucidating specific gene functions and for use in gene therapy. However, low activity, non-specific expression and size limitations in the vector are always problems. Here, we developed a 'double-unit' AdV containing the Cre gene under the control of an α-fetoprotein promoter near the right end of its genome and bearing a...
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