Article
Incorporating the survivin promoter in an infectivity enhanced CRAd-analysis of oncolysis and anti-tumor effects in vitro and in vivo.
International journal of oncology - 1 Jul 2005
Zhu Zeng B, Makhija Sharmila K, Lu Baogen, Wang Minghui, Rivera Angel A, Kim-Park Sangae, Ulasov Ilya V, Zhou Fen, Alvarez Ronald D, Siegal Gene P, Curiel David T
Abstract excerpt
Conditionally replicating adenoviruses (CRAds) represent a promising new modality for the treatment of cancer. A key contribution in this regard was the introduction of tumor-selective viral replication for amplification of the initial inoculum. Specifically, following cellular infection, the virus replicates selectively in the infected tumor cells and kills the cells by cytolysis. Next, the progeny virions...
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