Article
Targeting interferon-alpha increases antitumor efficacy and reduces hepatotoxicity of E1A-mutated spread-enhanced oncolytic adenovirus.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Mar 2007
Shashkova Elena V, Spencer Jacqueline F, Wold William S M, Doronin Konstantin
Abstract excerpt
Novel approaches are needed to improve the antitumor potency and to increase the cancer specificity of oncolytic adenoviruses (Ad). We hypothesized that the combination of interferon-alpha (IFN-alpha) expression with a specific mutation in the e1a gene of Ad could target vector replication to genetic defects in the IFN-alpha pathway resulting in both improved antitumor efficacy and reduced toxicity. The...
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