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Article

Utilizing alpha-fetoprotein expression to enhance oncolytic viral therapy in hepatocellular carcinoma.

Annals of surgery - 1 Oct 2004

Pin Richard H, Reinblatt Maura, Fong Yuman

Abstract excerpt

OBJECTIVE: To determine whether alpha-fetoprotein (AFP)-regulated ribonucleotide reductase (RR) production would promote more vigorous and specific viral killing in AFP-expressing hepatocellular carcinoma (HCC). BACKGROUND: AFP is expressed in over 70% of primary HCC but not in normal adult liver. AFP production by HCC can be exploited to target viral killing of tumor cells. G207 is an oncolytic herpes virus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15383793
DOI: 10.1097/01.sla.0000141197.57930.7a
PMCID: PMC1356467

Genes

AFP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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