Article
Inhibition of IL-8 gene expression in Caco-2 cells by compounds which induce histone hyperacetylation.
Cytokine - 1 Jan 1997
Huang N, Katz J P, Martin D R, Wu G D
Abstract excerpt
Ulcerative colitis, an idiopathic inflammatory disease of the colonic mucosa, can be effectively treated by enemas containing short chain fatty acids (SCFA) such as butyrate, propionate, and acetate. The molecular mechanisms that lead to this response have not been well characterized. It is well known that intestinal inflammation leads to an alteration in patterns of epithelial differentiation with an increase in...
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