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Article

An array of target-specific screening strains for antibacterial discovery.

Nature biotechnology - 1 May 2002

DeVito Joseph A, Mills Jonathan A, Liu Veronica G, Agarwal Anjana, Sizemore Christine F, Yao Zhongjie, Stoughton Daniel M, Cappiello Maria Grazia, Barbosa Maria D F S, Foster Lorie A, Pompliano David L

Abstract excerpt

As the global threat of drug- and antibiotic-resistant bacteria continues to rise, new strategies are required to advance the drug discovery process. This work describes the construction of an array of Escherichia coli strains for use in whole-cell screens to identify new antimicrobial compounds. We used the recombination systems from bacteriophages lambda and P1 to engineer each strain in the array for low-level...

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Share to Alkyl and Aryl Transferases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11981561
DOI: 10.1038/nbt0502-478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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