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Genetic Tools and Approaches to Study Bacterial Efflux Pumps.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2026

Caswell Megan R, Wright Mallory, Cox Georgina

Abstract excerpt

The substrate specificities and functions of bacterial efflux pumps are difficult to define due to the large number encoded in bacterial genomes, variations in gene expression, and functional redundancies. In this chapter, we describe the use of efflux-deficient Escherichia coli mutants as simplified genetic backgrounds for studying efflux pumps. We present detailed methodologies for introducing individual efflux...

Read the complete abstract on PubMed

Topics

Escherichia coli
Membrane Transport Proteins
Escherichia coli Proteins
Anti-Bacterial Agents
Mutation
Promoter Regions, Genetic

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Identifiers

PMID: 42681253
DOI: 10.1007/978-1-0716-5316-6_12

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