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Article

IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells.

Immunity - 1 Apr 2002

Manis John P, Dudley Darryll, Kaylor Lianne, Alt Frederick W

Abstract excerpt

To assess the role of the DNA-PKcs nonhomologous DNA end-joining (NHEJ) protein in Ig heavy chain class switch recombination (CSR), we assayed CSR ability of DNA-PKcs-deficient (DP-T) B cells generated via complementation of DP-T mice with Ig heavy chain and light chain knock-in transgenes (DP-T/HC/LC mice). DP-T/HC/LC mice were severely deficient for all serum IgH isotypes except IgM and, unexpectedly, IgG1....

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Source

Identifiers

PMID: 11970883
DOI: 10.1016/s1074-7613(02)00306-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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