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Restoration of T cell-specific V(D)J recombination in DNA-PKcs(-/-) mice by ionizing radiation: The effects on survival, development, and tumorigenesis.

Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica - 1 Mar 2002

Li Xiao-Ling, Shen Shou-Rong, Wang Sa, Ouyang Hong-Hai, Li Gloria C

Abstract excerpt

DNA-dependent protein kinase (DNA-PK) is a DNA-activated nuclear serine/threonine protein kinase. DNA-PK consists of a heterodimeric Ku subunit (composed of a 70 and 86 kD subunit) which binds DNA ends and targets the catalytic subunit DNA-PKcs to DNA strand breaks. DNA-PK plays a major role in the repair of double-strand breaks (DSB) induced in DNA after exposure to ionizing radiation. To better understand the...

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Share to DNA-Activated Protein Kinase
Share to Dose-Response Relationship, Radiation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gamma Rays

Share to Gene Rearrangement, T-Lymphocyte

Share to Immunoglobulin Joining Region

Share to Neoplasms, Radiation-Induced

Share to Receptors, Antigen, T-Cell, alpha-beta

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PMID: 12006988

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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