AID dysregulation in lupus-prone MRL/Faslpr/lprmice increases class switch DNA recombination and promotes interchromosomalc-Myc/IgHloci translocations: Modulation by HoxC4

Abstract excerpt

Immunoglobulin gene somatic hypermutation (SHM) and class switch DNA recombination (CSR) play important roles in the generation of autoantibodies in systemic lupus erythematosus. Systemic lupus is characterized by the production of an array of pathogenic high-affinity mutated and class-switched, mainly IgG, antibodies to a variety of self-antigens, including nuclear components, such as dsDNA, histones, and...

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