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Article

Genetic polymorphism in N-Acetyltransferase (NAT): Population distribution of NAT1 and NAT2 activity.

Journal of toxicology and environmental health. Part B, Critical reviews - 1 Jan 2009

Walker Katy, Ginsberg Gary, Hattis Dale, Johns Douglas O, Guyton Kathryn Z, Sonawane Babasaheb

Abstract excerpt

N-Acetyltransferases (NAT) are key enzymes in the conjugation of certain drugs and other xenobiotics with an arylamine structure. Polymorphisms in NAT2 have long been recognized to modulate toxicity produced by the anti-tubercular drug isoniazid, with molecular epidemiologic studies suggesting a link between acetylator phenotype and increased risk for bladder cancer. Recent evidence indicates that the other major...

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Source

Identifiers

PMID: 20183529
DOI: 10.1080/10937400903158383

Genes

NAT2
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic polymorphism in N-Acetyltransferase (NAT): Population distribution of NAT1 and NAT2 activity.PMID 20183529Read ↗

Human acetyltransferase polymorphisms.Semantic proximity Read ↗

Study of NAT2 gene polymorphisms in an Indian population: association with plasma isoniazid concentration in a cohort of tuberculosis patients.Semantic proximity Read ↗

Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms.Semantic proximity Read ↗

Expression and genotype-dependent catalytic activity of N-acetyltransferase 2 (NAT2) in human peripheral blood mononuclear cells and its modulation by Sirtuin 1.Semantic proximity Read ↗

A study of N-acetyltransferase 2 gene polymorphisms in the Indian population and its relationship with serum isoniazid concentrations in a cohort of tuberculosis patients.Semantic proximity Read ↗

Arylamine N-acetyltransferase acetylation polymorphisms: paradigm for pharmacogenomic-guided therapy- a focused review.Semantic proximity Read ↗

Analysis of nucleotide diversity of NAT2 coding region reveals homogeneity across Native American populations and high intra-population diversity.Semantic proximity Read ↗

NAT2 global landscape: Genetic diversity and acetylation statuses from a systematic review.Semantic proximity Read ↗

Population pharmacokinetics of isoniazid in adult Indian tuberculosis patients: Evaluation of NAT2 polymorphisms.Semantic proximity Read ↗

A simplified assay for the arylamine N-acetyltransferase 2 polymorphism validated by phenotyping with isoniazid.Semantic proximity Read ↗

N-acetyltransferase 2 genetic polymorphism: effects of carcinogen and haplotype on urinary bladder cancer risk.Semantic proximity Read ↗

Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.Semantic proximity Read ↗

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