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Article

The role of transmembrane helix 5 in agonist binding to the human H3 receptor.

The Journal of pharmacology and experimental therapeutics - 1 May 2002

Uveges Albert J, Kowal Dianne, Zhang Yingxin, Spangler Taylor B, Dunlop John, Semus Simon, Jones Philip G

Abstract excerpt

We have used alanine scanning mutagenesis to identify residues in transmembrane domain 5 of the histamine H3 receptor that are important for agonist binding. All of the mutants generated were functionally expressed as demonstrated by their ability to bind [(125)I]iodoproxyfan with comparable affinity to the wild-type receptor and their ability to inhibit forskolin-stimulated cAMP formation when activated by...

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PMID: 11961043
DOI: 10.1124/jpet.301.2.451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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