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Article

The loop C region of the murine 5-HT3A receptor contributes to the differential actions of 5-hydroxytryptamine and m-chlorophenylbiguanide.

Biochemistry - 28 Jun 2005

Suryanarayanan Asha, Joshi Prasad R, Bikádi Zsolt, Mani Muthalagi, Kulkarni Trupti R, Gaines Chandra, Schulte Marvin K

Abstract excerpt

Sequence and predicted structural similarities between members of the Cys loop superfamily of ligand-gated ion channel receptors and the acetylcholine binding protein (AChBP) suggest that the ligand-binding site is formed by six loops that intersect at subunit interfaces. We employed site-directed mutagenesis to investigate the role of amino acids from the loop C region of the murine 5-HT(3AS)R in interacting...

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PMID: 15966738
DOI: 10.1021/bi050661e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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