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Article

Linking agonist binding to histamine H1 receptor activation.

Nature chemical biology - 1 Jul 2005

Jongejan Aldo, Bruysters Martijn, Ballesteros Juan A, Haaksma Eric, Bakker Remko A, Pardo Leonardo, Leurs Rob

Abstract excerpt

G protein-coupled receptors (GPCRs) constitute a large and functionally diverse family of transmembrane proteins. They are fundamental in the transfer of extracellular stimuli to intracellular signaling pathways and are among the most targeted proteins in drug discovery. The detailed molecular mechanism for agonist-induced activation of rhodopsin-like GPCRs has not yet been described. Using a combination of...

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Identifiers

PMID: 16408006
DOI: 10.1038/nchembio714

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