Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The naturally occurring mutation Y197C does not affect the expression or signaling of the human histamine H3 receptor.

Neuroscience letters - 22 Feb 2017

Flores-Clemente Cecilia, Escamilla-Sánchez Juan, Arias Juan-Manuel, Arias-Montaño José-Antonio

Abstract excerpt

There is evidence for genetic polymorphism within the human histamine H3 receptor (hH3R), and a Tyr to Cys exchange at position 197 (Y197C), located in the amino terminus of the fifth transmembrane domain, has been reported. In this work we compared the expression and the pharmacological and signaling properties of wild-type (hH3RWT) and mutant (hH3RY197C) receptors transiently expressed in CHO-K1 cells. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CHO Cells
Share to Cricetulus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP

Share to Mutation

Share to Radioligand Assay

Share to Signal Transduction

Source

Identifiers

PMID: 28126588
DOI: 10.1016/j.neulet.2017.01.048

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The naturally occurring mutation Y197C does not affect the expression or signaling of the human histamine H3 receptor.PMID 28126588Read ↗

Pharmacological characterization of seven human histamine H <sub>3</sub> receptor isoformsSemantic proximity Read ↗

Structure of the human histamine H3 receptor gene (HRH3) and identification of naturally occurring variations.Semantic proximity Read ↗

Pharmacological Characterization of Human Histamine Receptors and Histamine Receptor Mutants in the Sf9 Cell Expression System.Semantic proximity Read ↗

Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor.Semantic proximity Read ↗

Recovery of histamine H3 receptor activity lost in yeast cells through error-prone PCR and in vivo selectionSemantic proximity Read ↗

Generation and characterization of highly constitutive active histamine H3 receptors.Semantic proximity Read ↗

The hydrophobic amino acids in putative helix 8 in carboxy-terminus of histamine H(3) receptor are involved in receptor-G-protein coupling.Semantic proximity Read ↗

The rat H3 receptor: gene organization and multiple isoforms.Semantic proximity Read ↗

G649, an allelic variant of the human H2 receptor with low basal activity, is resistant to upregulation upon antagonist exposure.Semantic proximity Read ↗

The role of transmembrane helix 5 in agonist binding to the human H3 receptor.Semantic proximity Read ↗

The naturally occurring Arg219Leu variant of the human 5-HT1A receptor: impairment of signal transduction.Semantic proximity Read ↗

A280V polymorphism in the histamine H3 receptor as a risk factor for migraine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.