Article
The hydrophobic amino acids in putative helix 8 in carboxy-terminus of histamine H(3) receptor are involved in receptor-G-protein coupling.
Cellular signalling - 1 Nov 2011
Kuramasu Atsuo, Sukegawa Jun, Sato Takeya, Sakurai Eiko, Watanabe Takehiko, Yanagisawa Teruyuki, Yanai Kazuhiko
Abstract excerpt
Functional roles of putative helix 8 in the carboxy-terminal tail of the human histamine H(3) receptor were investigated using deleted and alanine-substituted mutant receptors. While the deletion of the carboxy-terminal tail did not decrease the total expression level, surface expression, or ligand binding affinity, the agonist-stimulated cAMP response, [((35))S] GTPγS binding, and MAPK activation were totally...
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