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Article

Molecular determinants of ligand binding to H4R species variants.

Molecular pharmacology - 1 May 2010

Lim Herman D, de Graaf Chris, Jiang Wen, Sadek Payman, McGovern Patricia M, Istyastono Enade P, Bakker Remko A, de Esch Iwan J P, Thurmond Robin L, Leurs Rob

Abstract excerpt

The histamine H(4) receptor (H(4)R) is the latest identified histamine receptor to emerge as a potential drug target for inflammatory diseases. Animal models are employed to validate this potential drug target. Concomitantly, various H(4)R orthologs have been cloned, including the human, mouse, rat, guinea pig, monkey, pig, and dog H(4)Rs. In this article, we expressed all these H(4)R orthologs in human embryonic...

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PMID: 20103609
DOI: 10.1124/mol.109.063040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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