Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain.

British journal of pharmacology - 1 Dec 2000

Ligneau X, Morisset S, Tardivel-Lacombe J, Gbahou F, Ganellin C R, Stark H, Schunack W, Schwartz J C, Arrang J M

Abstract excerpt

Starting from the sequence of the human histamine H(3) receptor (hH(3)R) cDNA, we have cloned the corresponding rat cDNA. Whereas the two deduced proteins show 93.5% overall homology and differ only by five amino acid residues at the level of the transmembrane domains (TMs), some ligands displayed distinct affinities. Thioperamide and ciproxifan were about 10 fold more potent at the rat than at the human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acids
Share to Binding, Competitive

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to COS Cells

Share to DNA, Complementary

Share to Imidazoles

Share to Piperidines

Share to Radioligand Assay

Share to Tritium

Source

Open in PubMed Open full text

Identifiers

PMID: 11090094
DOI: 10.1038/sj.bjp.0703712
PMCID: PMC1572469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain.PMID 11090094Read ↗

Molecular determinants of ligand binding to H4R species variants.Semantic proximity Read ↗

Pharmacological characterization of seven human histamine H <sub>3</sub> receptor isoformsSemantic proximity Read ↗

The rat H3 receptor: gene organization and multiple isoforms.Semantic proximity Read ↗

Comparison of Human, Mouse, Rat, and Guinea Pig Histamine H4 Receptors Reveals Substantial Pharmacological Species VariationSemantic proximity Read ↗

Structural studies on histamine receptorsSemantic proximity Read ↗

Generation and characterization of highly constitutive active histamine H3 receptors.Semantic proximity Read ↗

New developments in the use of histamine and histamine receptors.Semantic proximity Read ↗

Structure of the human histamine H3 receptor gene (HRH3) and identification of naturally occurring variations.Semantic proximity Read ↗

Molecular pharmacological aspects of histamine receptorsSemantic proximity Read ↗

The role of histamine H 4 receptor in immune and inflammatory disordersSemantic proximity Read ↗

Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor.Semantic proximity Read ↗

Pharmacological Characterization of Human Histamine Receptors and Histamine Receptor Mutants in the Sf9 Cell Expression System.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.