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Article

Mutagenesis and molecular modeling reveal the importance of the 5-HT3 receptor F-loop.

The Journal of biological chemistry - 16 Jun 2006

Thompson Andrew J, Padgett Claire L, Lummis Sarah C R

Abstract excerpt

The 5-HT(3) receptor is a member of the Cys-loop family of ligand-gated ion channels. The extracellular domains of these proteins contain six amino acid loops (A-F) that converge to form the ligand binding site. In this study we have mutated 21 residues in or close to the 5-HT(3) receptor F-loop (Ile(192) to Gly(212)) to Ala or to a residue with similar chemical properties. Mutant receptors were expressed in...

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Source

Identifiers

PMID: 16595668
DOI: 10.1074/jbc.M601265200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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