Article
The M4 transmembrane segment contributes to agonist efficacy differences between alpha1 and alpha3 glycine receptors.
Molecular membrane biology - 1 Aug 2009
Chen Xuebin, Webb Timothy I, Lynch Joseph W
Abstract excerpt
To date there are few compounds known to pharmacologically discriminate between alpha1 and alpha3 subunit-containing glycine receptors (GlyRs). The present study stemmed from an observation that the glycinergic agonists, taurine and beta-alanine, act with much lower agonist efficacy at alpha3 GlyRs than at alpha1 GlyRs. We sought to understand the structural basis of this difference to provide insights relevant...
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