Article
Lethal comatose mutation in Drosophila reveals possible role for NSF in neurogenesis.
Neuroreport - 25 May 2001
Sanyal S, Krishnan K S
Abstract excerpt
NSF is a cytosolic ATPase implicated in a variety of cellular functions including synaptic vesicle exocytosis. Here we report a lethal mutation in the Drosophila homolog of NSF (dNSF1). Lethality staging and rescue experiments with the wild type dNSF1 transgene show that NSF1 is critically required during early larval stages and during late pupariation. Lethality in larval stages is associated with defects in...
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