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The novel MMS‐inducible gene <i>Mif1/KIAA0025</i> is a target of the unfolded protein response pathway

3 Mar 2000

Abstract excerpt

In a search for genes induced by DNA-damaging agents, we identified two genes that are activated by methyl methanesulfonate (MMS). Expression of both genes is regulated after endoplasmic reticulum (ER) stress via the unfolded protein response (UPR) pathway. The first gene of those identified is the molecular chaperone BiP/GRP78. The second gene, Mif1, is identical to the anonymous cDNA KIAA0025. Treatment with...

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PMID: 10708769
DOI: 10.1016/s0014-5793(00)01253-9

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