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Article

Analysis of gene transcription in cells lacking DNA-PK activity.

Radiation research - 1 Aug 2001

Bryntesson F, Regan J C, Jeggo P A, Taccioli G E, Hubank M

Abstract excerpt

The DNA-dependent protein kinase (DNA-PK), comprised of the Ku70/Ku80 (now known as G22p1/Xrcc5) heterodimer and the catalytic subunit DNA-PKcs (now known as Prkdc), is required for the nonhomologous end joining (NHEJ) pathway of DNA double-strand break repair. The mechanism of action of DNA-PK remains unclear. We have investigated whether DNA-PK regulates gene transcription in vivo after DNA damage using the...

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Identifiers

PMID: 11448237
DOI: 10.1667/0033-7587(2001)156[0167:aogtic]2.0.co;2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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