Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic evolution of T-cell resistance in the course of melanoma progression.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2014

Sucker Antje, Zhao Fang, Real Birgit, Heeke Christina, Bielefeld Nicola, Maβen Stefan, Horn Susanne, Moll Iris, Maltaner Raffaela, Horn Peter A, Schilling Bastian, Sabbatino Francesco, Lennerz Volker, Kloor Matthias, Ferrone Soldano, Schadendorf Dirk, Falk Christine S, Griewank Klaus, Paschen Annette

Abstract excerpt

PURPOSE: CD8(+) T lymphocytes can kill autologous melanoma cells, but their activity is impaired when poorly immunogenic tumor phenotypes evolve in the course of disease progression. Here, we analyzed three consecutive melanoma lesions obtained within one year of developing stage IV disease for their recognition by autologous T cells. EXPERIMENTAL DESIGN: One skin (Ma-Mel-48a) and two lymph node (Ma-Mel-48b,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta 2-Microglobulin
Share to Cytokines

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to Lymphocytes, Tumor-Infiltrating

Share to Melanoma

Share to Neoplasm Metastasis

Share to Neoplasm Staging

Share to T-Lymphocyte Subsets

Source

Open in PubMed Open full text

Identifiers

PMID: 25294904
DOI: 10.1158/1078-0432.CCR-14-0567
PMCID: PMC8728890

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic evolution of T-cell resistance in the course of melanoma progression.PMID 25294904Read ↗

Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions.Semantic proximity Read ↗

Immune escape of cancer cells with beta2-microglobulin loss over the course of metastatic melanoma.Semantic proximity Read ↗

Phenotypic tumour cell plasticity as a resistance mechanism and therapeutic target in melanoma.Semantic proximity Read ↗

Melanoma Lesions Independently Acquire T-cell Resistance during Metastatic LatencySemantic proximity Read ↗

Cancer Cell Phenotype Plasticity as a Driver of Immune Escape in Melanoma.Semantic proximity Read ↗

Cancer immunoediting by melanocyte differentiation antigen-specific T cells determines response to immune checkpoint inhibitionSemantic proximity Read ↗

Model-based genotype-phenotype mapping used to investigate gene signatures of immune sensitivity and resistance in melanoma micrometastasis.Semantic proximity Read ↗

Characterization of HLA class I altered phenotypes in a panel of human melanoma cell lines.Semantic proximity Read ↗

beta2-Microglobulin mutations, HLA class I antigen loss, and tumor progression in melanoma.Semantic proximity Read ↗

A natural cytotoxic T cell response in a spontaneously regressing human melanoma targets a neoantigen resulting from a somatic point mutationSemantic proximity Read ↗

MELOE-1 is a new antigen overexpressed in melanomas and involved in adoptive T cell transfer efficiencySemantic proximity Read ↗

HLA-B8 association with late-stage melanoma--an immunological lesson?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.