Article
Allelotyping of esophageal squamous-cell carcinoma on chromosome 13 defines deletions related to family history.
Genes, chromosomes & cancer - 1 Nov 2005
Hu Nan, Su Hua, Li Wen Jun, Giffen Carol, Goldstein Alisa M, Hu Ying, Wang Chaoyu, Roth Mark J, Li Guang, Dawsey Sanford M, Xu Yi, Taylor Philip R, Emmert-Buck Michael R
Abstract excerpt
We previously reported that esophageal squamous-cell cancers (ESCC) from Shanxi Province in China show frequent allelic loss on chromosome 13. Moreover, tumors from patients with a positive family history of upper gastrointestinal tumors exhibit more frequent loss of heterozygosity (LOH) on this chromosome than do those from patients without a family history. These results suggest the possibility of a familial...
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