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Article

Evaluation of BRCA2 in the genetic susceptibility of familial esophageal cancer.

Oncogene - 22 Jan 2004

Hu Nan, Wang Chaoyu, Han Xiao-You, He Li-Ji, Tang Ze-Zhong, Giffen Carol, Emmert-Buck Michael R, Goldstein Alisa M, Taylor Philip R

Abstract excerpt

Previous studies of esophageal squamous cell carcinoma (ESCC) have shown a high frequency of allelic loss on chromosome 13q, infrequent somatic mutations in BRCA2, and a suggested association between a positive family history (FH+) of upper gastrointestinal cancer and germline BRCA2 mutations. In all, 70 ESCC patients (44 FH+ and 26 FH-) were examined by direct full sequencing of germline DNA for BRCA2 mutations....

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Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 13

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Share to Genes, BRCA2

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Source

Identifiers

PMID: 14647438
DOI: 10.1038/sj.onc.1207150

Genes

BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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