Article
Analyses of bulky DNA adduct levels in human breast tissue and genetic polymorphisms of cytochromes P450 (CYPs), myeloperoxidase (MPO), quinone oxidoreductase (NQO1), and glutathione S-transferases (GSTs).
Mutation research - 26 Apr 2002
Brockstedt Ulrike, Krajinovic Maja, Richer Chantal, Mathonnet Geraldine, Sinnett Daniel, Pfau Wolfgang, Labuda Damian
Abstract excerpt
Environmental carcinogens are converted into DNA-reactive metabolites by phase I and phase II enzymes that are involved in the activation and detoxification of xenobiotics. Several of these enzymes display genetic polymorphisms that alter their activity leading to individual variation in DNA damage levels and thus cancer susceptibility. We investigated the relationship between DNA adduct levels and genetic...
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