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Article

The GSTM1null (deletion) and MGMT84 rs12917 (Phe/Phe) haplotype are associated with bulky DNA adduct levels in human leukocytes.

Mutation research. Genetic toxicology and environmental mutagenesis - 12 Dec 2013

Molina Edith, Pérez-Morales Rebeca, Rubio Julieta, Petrosyan Pavel, Cadena Leticia Hernández, Arlt Volker M, Phillips David H, Gonsebatt María E

Abstract excerpt

Tobacco smoke and air pollutants contain carcinogens, such as polycyclic aromatic hydrocarbons (PAHs) and tobacco specific nitrosamines (TSNA), that are substrates of metabolizing enzymes generating reactive metabolites that can bind to DNA. Variation in the activity of these enzymes may modify the extent to which these metabolites can interact with DNA. We compared the levels of bulky DNA adducts in blood...

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Topics

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Share to DNA Adducts
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukocytes

Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 24084248
DOI: 10.1016/j.mrgentox.2013.09.007

Genes

GSTM1
MGMT
EPHX1
ERCC2
GSTP1
GSTT1
PAH
XRCC1

Provenance

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