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Article

A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk.

Breast cancer research and treatment - 1 Feb 2009

He Chunyan, Tamimi Rulla M, Hankinson Susan E, Hunter David J, Han Jiali

Abstract excerpt

Oxidative stress may be involved in breast carcinogenesis. Myeloperoxidase (MPO) is an endogenous oxidant enzyme that generates reactive oxygen species (ROS). A single nucleotide polymorphism (SNP) G-463A in the promoter region has been associated with a decrease in risk of breast cancer. We assessed the association between this polymorphism and breast cancer risk in a nested case-control study within the Nurses'...

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Source

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Identifiers

PMID: 18340529
DOI: 10.1007/s10549-008-9962-z
PMCID: PMC2664827

Genes

MPO
COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk.PMID 18340529Read ↗

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Common genetic variants in the myeloperoxidase and paraoxonase genes and the related cancer risk: a review.Semantic proximity Read ↗

Analyses of bulky DNA adduct levels in human breast tissue and genetic polymorphisms of cytochromes P450 (CYPs), myeloperoxidase (MPO), quinone oxidoreductase (NQO1), and glutathione S-transferases (GSTs).Semantic proximity Read ↗

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