Article
Aromatic DNA adducts and polymorphisms of CYP1A1, NAT2, and GSTM1 in breast cancer.
Carcinogenesis - 1 Feb 2002
Firozi Pervez F, Bondy Melissa L, Sahin Aysegul A, Chang Ping, Lukmanji Farzana, Singletary Eva S, Hassan Manal M, Li Donghui
Abstract excerpt
Previous studies by us and others have shown a significantly higher level of aromatic DNA adducts in normal adjacent breast tissue samples obtained from breast cancer patients than in those obtained from non-cancerous controls. The increased amount of DNA damage could be related to excess environmental carcinogen exposure and/or genetic susceptibility to such exposure. In the current study, we investigated the...
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