Article
Psoriatic lesional keratinocytes promote the maturation of human monocyte-derived Langerhans cells.
Dermatology (Basel, Switzerland) - 1 Jan 2002
Yu Yizhi, Tang Ling, Wang Jianli, Liu Shuxun, Wang Wengya, An Huazhang, Qi Runzi, Zhang Minghui, Cao Xuetao
Abstract excerpt
BACKGROUND: Langerhans cells (LCs) are important antigen-presenting cells in the epidermis and may play a key role in the pathogenesis of psoriasis. It has been proven that LCs isolated from psoriatic lesions are abnormal. However, the mechanism of the abnormality has not been reported so far. OBJECTIVE: In the present study, we investigated the effect of psoriatic lesional keratinocytes on the maturation of LCs....
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