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Article

Impaired Langerhans cell migration in psoriasis is due to an altered keratinocyte phenotype induced by interleukin-17.

The British journal of dermatology - 1 Jun 2018

Eaton L H, Mellody K T, Pilkington S M, Dearman R J, Kimber I, Griffiths C E M

Abstract excerpt

BACKGROUND: Psoriasis is a common skin condition driven by increased expression of interleukin (IL)-17. Langerhans cells (LCs) are epidermal dendritic cells that regulate cutaneous immune responses. Within the uninvolved skin of patients with psoriasis, LCs display impaired migration from the epidermis. OBJECTIVES: To investigate the role of keratinocytes (KCs) in the regulation of LC function and the response of...

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Source

Identifiers

PMID: 29194565
DOI: 10.1111/bjd.16172

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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