Article
Variability of X chromosome inactivation: effect on levels of TIMP1 RNA and role of DNA methylation.
Human genetics - 1 Mar 2002
Anderson Catherine L, Brown Carolyn J
Abstract excerpt
X chromosome inactivation results in dosage equivalency for X-linked gene expression between males and females. However, some X-linked genes show variable X inactivation, being expressed from the inactive X in some females but subject to inactivation in other women. The human tissue inhibitor of metalloproteinases-1 ( TIMP1) gene falls into this category. As TIMP1 and its target metalloproteinases are involved in...
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