Article
Targeted disruption of the tissue inhibitor of metalloproteinases gene increases the invasive behavior of primitive mesenchymal cells derived from embryonic stem cells in vitro.
The Journal of cell biology - 1 Aug 1992
Alexander C M, Werb Z
Abstract excerpt
The metalloproteinase family of proteolytic enzymes can degrade extracellular matrix and facilitate invasive migration. This class of enzymes is specifically inhibited by the tissue inhibitor of metalloproteinases (TIMP-1). Using homologous recombination, we have disrupted the gene encoding TIMP-...
Topics
- Base Sequence
- Cell Differentiation
- Cell Division
- Cell Movement
- Connective Tissue
- Connective Tissue Cells
- DNA
- Glycoproteins
- Intermediate Filaments
- Mesoderm
- Metalloendopeptidases
- Molecular Sequence Data
- Phenotype
- Restriction Mapping
- Stem Cells
- Tissue Inhibitor of Metalloproteinases