Article
Disruption of the TIMP-1 gene product is associated with accelerated endometrial gland formation during early postnatal uterine development.
Biology of reproduction - 1 Aug 2004
Zhou Han-E, Zhang Xuan, Nothnick Warren B
Abstract excerpt
Postnatal uterine development is marked by periods of tissue remodeling. The objective of the present study was to examine the role of tissue inhibitor of metalloproteinase-1 (TIMP-1), a regulator of tissue remodeling events, during postnatal uterine development and to assess the phenotypic consequences of disruption of the TIMP-1 gene product during this time period. To accomplish this goal, wild-type and TIMP-1...
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